Efficacy and safety of recombinant human erythropoietin to prevent the anaemias of prematurity. European Randomized Multicenter Trial.
نویسندگان
چکیده
Michael Obladen, Rolf Maier, Hugo Segerer'\ E. Ludwig Grauel, Barbara M. Holland, Graham Stewart, Gerhard Jorch, Heike Rabe, Otwin Linderkamp, H. G. Hoffmann, Frieda Houghton, Zuzana Herrmann, Paul Scigalla, Charles War drop Department of Neonatology, University Children's Hospital, Free University, Berlin, FRG; Department of Neonatology, Charite Children's Hospital, Humboldt University, Berlin, G D R ; "Department of Paediatrics, Queen Mother's Hospital, University of Glasgow, UK; d University Children's Hospital, Münster, FRG; ' Department of Neonatology, University Children's Hospital, Heidelberg, FRG; 'Clinical Research Department, MCP Pharmaceuticals, Livingston, UK; Boehringer Mannheim GmbH, Mannheim, FRG; Department of Haematology, University of Wales, College of Medicine, Cardiff, UK
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Erythropoietin (EPO) was first known as a factor for red blood cell proliferation and differentiation. Recent studies show the effects of EPO on immune system. In this study the antihuman leukocyte antibody (anti-HLA) titer were determined in five groups of rats, which had been sensitized with human lymphocyte. Also, the effects of stimulation's frequency and dose of recombinant human erythropo...
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عنوان ژورنال:
- Contributions to nephrology
دوره 88 شماره
صفحات -
تاریخ انتشار 1991